Abstract | To select Chinese medicine Eriobotrya japonica (Thunb.) Lindl. leaves with high hypoglycemic activity, contents of total ashes, extracts and triterpenoid acid components in crude and processed products of mature leaves and fallen leaves of E. japonica from Xishan Island in Suzhou of Jiangsu in November were compared, and their ability to inhibit α-glucosidase activity was also compared. The results show that contents of total ashes and extracts in different types of E. japonica leaves are in accord with related criteria. Contents of each triterpenoid acid component in fallen leaves are significantly higher than those in mature leaves in general, and total contents of triterpenoid acid components in crude and processed products of mature leaves, and crude and processed products of fallen leaves are 1.671 0%, 1.690 0%, 3.774 1%, and 2.717 5%, respectively. α-glucosidase inhibitory activity of different types of E. japonica leaves is significantly higher than that of acarbose, in which, half-inhibitory concentration (IC50) of crude product of fallen leaves is the lowest with only 64.170 μg·mL-1. In conclusion, fallen leaves are the optimum choice for taking E. japonica leaves as hypoglycemic Chinese medicine. |
| 关键词 | 枇杷叶; 成熟叶; 落叶; HPLC-ELSD; 三萜酸类成分; α-葡萄糖苷酶 |
| Key words | Eriobotrya japonica (Thunb.) Lindl. leaf; mature leaf; fallen leaf; HPLC-ELSD; triterpenoid acid component; α-glucosidase |
| 作者 | 吴月娴, 吕寒, 简暾昱, 陈剑, 马丽, 任冰如, 李维林 |
| 所在单位 | 江苏省中国科学院植物研究所(南京中山植物园) 江苏省抗糖尿病药物筛选技术服务中心, 江苏 南京 210014 |
| 点击量 | 23258 |
| 下载次数 | 2963 |
| 基金项目 | 江苏省重点研发计划-社会发展面上项目(BE2015690); 江苏省科技基础设施建设计划-科技公共服务平台项目(BM2011117) |